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From: bhirsch@vais.net (Barbara Hirsch)
Newsgroups: alt.support.diet.rx
Subject: Re: Phen/Dex
Date: Wed, 10 Sep 1997 03:10:59 GMT
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mediedpres@aol.com (MediEdPres) wrote:
>Weintraub studies had considerable experience in the phen/fen combination
>but that there was little or no experience with phen/dex. 
Weintraub never tested phentermine and dexfenfluramine. He conducted 2
studies on phen/fen, one on sibutramine. I threw in the Acutrim one
for giggles.
Long-term weight control: the National Heart, Lung, and Blood
Institute funded multimodal intervention study  Clin Pharmacol Ther
1992 May;51(5):581-585  (This is the famous phen/fen study).
Sibutramine in weight control: a dose-ranging, efficacy study.  Clin
Pharmacol Ther 1991 Sep;50(3):330-337 
Phenylpropanolamine OROS (Acutrim) vs. placebo in combination with
caloric restriction and physician-managed behavior modification. Clin
Pharmacol Ther 1986 May;39(5):501-509 (this was on Acutrim)
A double-blind clinical trial in weight control. Use of fenfluramine
and phentermine alone and in combination. Arch Intern Med 1984
Jun;144(6):1143-1148 
>reason given for that is that dex had only been available abroad and that
>phen was not available there (but this is where I may be wrong in
>recollection).
That shouldn't make any difference when you're doing a clinical trial.
Sibutramine wasn't (and still isn't) available here, but Weintraub did
a clinical study on it in 1991.
You're the same guy that jumped all over my case over St. John's Wort,
right?
>I did notice that one of the major weight loss chains has switched to a
>phen/prozac approach and it would seem there would not be much data there
>either.
Actually there is data on prozac and weight loss. Three clinical
studies in the early 90s. Said it didn't do shit, at least on its own.
MediEdPres? I hope you're not publishing your opinions.
Barbara
Barbara Hirsch, Editor
Obesity Meds and Research News
September authors: Dr. Dennis Tison and Dr. Richard Rothman
OMR Web Site: http://www.obesity-news.com
.
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