phillip smith wrote:
> in article but4km$l8j$1{at}darwin.ediacara.org, Anon. at
> bob.ohara{at}SOD.OFF.Spammers.helsinki.fi wrote on 24/1/04 7:51 PM:
> 
> 
>>But you need linkage disequilibrium (LD) as well as epistasis to change
>>the effects of a single gene.  LD is reduced by recombination, so you'd
>>need the interacting genes to be close to each other, or for the
>>epistasis to be large, for the affect to be appreciable.
>>
> 
> This is true of the epistatic interactions are limited to  a single allele
> of a single gene at a limited stretch of the genome. For this to be true the
> rest of the genome must be considered static. I doubt this ever occurs or
> occurs out side of the lab with sufficient frequency to matter.
> To illustrate my point take the rest of the genome save the gene we are
> interested in and cinsider  it all as being one gene. How many alleles are
> there and what is the epistatic effects on that on the coefficent of
> selection of the gene we are examining?

Well, if we're considering all of the interacting genes, then clearly 
the epistatic interactions with the rest of the genome are zero.

Bob

-- 
Bob O'Hara

Dept. of Mathematics and Statistics
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