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| subject: | Re: RNA - 100% Fidelity i |
<< JM Ok, but RNA does NOT survive in the environment you are talking about: Matthew Levy and Stanley L. Miller The stability of the RNA bases: Implications for the origin of life PNAS 1998; 95: 7933-7938. http://www.pnas.org/cgi/reprint/95/14/7933 Excerpt: We show here that the rapid rates of hydrolysis of the nucleobases A, U, G, C, and T at temperatures much above 0°C would present a major problem in the accumulation of these presumed essential compounds on the early Earth. A high-temperature origin of life involving these compounds therefore is unlikely. TH This is a very real problem with my scenerio. Also with the evidence pointing to early life developing in such a hot environment. NEW TH I got to read this and think about it some more. This is a very real problem with ALL scenarios if it is right - but I'm not so sure it would prevent life from happening. Note that it seems Mars had water. That means that if mars was up to 0-100C, then closer-to-the-sun Earth must have been HOT. Miller/Levy says no way. Also they point to the problem of hydrolysis - but what if there was a dry phase. Also they mention how long these bases would last (if there is not a single way that they are getting an once of help from any other source) - which equals a wide range that is not completely prohibitive though it is pretty short. In the end I think there is lack of knowledge here to fit all the facts together. I can't escape the fact that it seems the earth was HOT. How then do these bases survive? Solving that may tie them in with amino acids and give the reason why RNA needed protein in the first place. I see your point but am not completely convinced. Also remember that each selected step in life gives greater thermal stability - folding of a strand over non folding, paired strands over single, WC base pairing over other less stable types, base stacking over not base stacking - etc. And I add this - why does RNA have such a high Tm (higher than even DNA) if it never was selected for needing it? Comment? --- þ RIMEGate(tm)/RGXPost V1.14 at BBSWORLD * Info{at}bbsworld.com --- * RIMEGate(tm)V10.2áÿ* RelayNet(tm) NNTP Gateway * MoonDog BBS * RgateImp.MoonDog.BBS at 5/13/04 1:39:51 PM* Origin: MoonDog BBS, Brooklyn,NY, 718 692-2498, 1:278/230 (1:278/230) SEEN-BY: 633/267 270 @PATH: 278/230 10/345 106/1 2000 633/267 |
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