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Part 3 of 5
poison was Dr. Gold's plan of attack. As he explains, "Each of these
processes [the
tumor invasion of vital organs and cachexia] has its own metabolic
machinery, each
is amenable to its own therapy, and each is to some degree functionally
interdependent on the other. In the interest of treating the totality of
malignant
disease, each of these processes warrants intervention. Such an
approach, dealing
with both major underpinnings of the cancerous process mitogenic and
metabolic affords the greatest promise for eliciting long-term,
symptom-free
survival and the potential for disease eradication."
But what causes cachexia? Cancer cells gobble up sugar ten to fifteen
times more
than normal cells do. The sugar consumed by the cancer cells is
generated mainly
from the liver, which converts lactic acid into glucose. (Normal cells
are far more
efficient users of glucose, which they derive from the food we eat, not
from lactic
acid.) When cancer cells use sugar (glucose) as fuel, they only
partially metabolize it.
Lactic acid the waste product of this incomplete combustion spills into
the
blood and is taken up by the liver. The liver then recycles the lactic
acid (and other
breakdown products) back into glucose, and the sugar is consumed in
ever-increasing amounts by voracious cancer cells. The result is a
vicious cycle,
what Dr. Gold calls a "sick relationship" between the liver and the
cancer. The
patient's healthy cells starve while the cancer cells grow vigorously.
Some healthy
cells even dissolve to feed the growing tumor.
To break this sick relationship, Gold reasoned, all he needed was to
find a safe,
nontoxic drug that inhibits g1uconeogenesis ( the liver's recycling of
lactic acid back
into glucose). In 1968, he outlined his theory in an article published
in Oncology.
"The silence was deafening,he recalls.
A year later, by a remarkable coincidence, Gold heard biochemist Paul
Ray deliver
a paper explaining that hydrazine sulfate could shut down the enzyme
necessary for
the production of glucose from lactic acid. Gold had chanced upon an
eminently
logical way of starving cancer. He immediately tested hydrazine sulfate
on mice and
found that in accord with his theory, the drug inhibited both
gluconeogenesis and
tumor growth.
Over the years, many dramatic remissions in patients on hydrazine
sulfate therapy
have been reported. In one case, a sixty-two-year-old woman with widely
disseminated cancer of the cervix, in a very debilitated condition, was
put on the
drug. After one week, a secondary tumor the size of an orange had
completely
disappeared, much to the amazement of the woman's doctors, and neck
nodes had
become markedly smaller. After three weeks on the therapy, the patient
had gained
weight and was active and in good spirits. The woman was discharged from
the
hospital a short time later.
In 1987, Erna Kamen, a sixty-three-year-old lung cancer patient, was
administered
hydrazine sulfate after her discharge from a Sarasota, Florida,
hospital. "Basically,
my mother was sent home to die," says Jeff Kamen, an Emmy-winning
television
reporter. "She'd lost a significant amount of weight by then, and she
had no appetite
and virtually no will to do anything." A doctor had told Jeff's father,
Ira Kamen, that
hydrazine sulfate offered at least "a shot in the dark." So one Monday
in August
1987, a home nurse gave Mrs. Kamen one hydrazine sulfate pill shortly
before
serving lunch. "On Tuesday morning," recalls Jeff, "there was a
commotion in the
house. My mother had risen from her bed like the phoenix rising from the
ashes. She
was demanding that the nurse bring her downstairs so that she could have
breakfast
with me.... When people you love get into this kind of facedown with
death, you're
just incredibly grateful for each moment."
As Jeff describes his mother's recovery, "her searing pain was gone; her
appetite
See part 4 of 5
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