An expanding genetic code
T. Ashton Croppa and Peter G. Schultzb,

Available online 13 October 2004.

More than 30 novel amino acids have been genetically encoded in response to
unique triplet and quadruplet codons including fluorescent, photoreactive
and redox active amino acids, glycosylated and heavy atom derived amino
acids in addition to those with keto, azido and acetylenic chains. In this
article, we describe recent advances that make it possible to add new
building blocks systematically to the genetic codes of bacteria, yeast and
mammalian cells. Taken together these tools will enable the detailed
investigation of protein structure and function, which is not possible with
conventional mutagenesis. Moreover, by lifting the constraints of the
existing 20-amino-acid code, it should be possible to generate proteins and
perhaps entire organisms with new or enhanced properties.

Full Text at Science Direct
icbeDA&tid=WbiddiiDB
Posted by
Robert Karl Stonjek
---
þ RIMEGate(tm)/RGXPost V1.14 at BBSWORLD * Info{at}bbsworld.com

---
 * RIMEGate(tm)V10.2áÿ* RelayNet(tm) NNTP Gateway * MoonDog BBS
 * RgateImp.MoonDog.BBS at 12/6/04 6:36:09 AM